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Structure paper

TitleBiochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Journal, issue, pagesBiochemistry, Vol. 62, Page 1124-1137, Year 2023
Publish dateDec 6, 2022 (structure data deposition date)
AuthorsKan, Y. / Paung, Y. / Kim, Y. / Seeliger, M.A. / Miller, W.T.
External linksBiochemistry / PubMed:36854171
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-8fe9:
Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-WTP:
5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / tyrosine kinase / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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