Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance.
Journal, issue, pages	Nat Commun, Vol. 16, Page 3156-3156, Year 2025
Publish date	Nov 15, 2022 (structure data deposition date)
Authors	Waterbury, A.L. / Caroli, J. / Zhang, O. / Tuttle, P.R. / Liu, C. / Li, J. / Park, J.S. / Hoenig, S.M. / Barone, M. / Furui, A. ...Waterbury, A.L. / Caroli, J. / Zhang, O. / Tuttle, P.R. / Liu, C. / Li, J. / Park, J.S. / Hoenig, S.M. / Barone, M. / Furui, A. / Mattevi, A. / Liau, B.B.
External links	Nat Commun / PubMed:40175327
Methods	X-ray diffraction
Resolution	2.72 - 3.41 Å
Structure data	PDB-8bop: LSD1-CoREST in complex with AW4, long soaking Method: X-RAY DIFFRACTION / Resolution: 2.74 Å PDB-8box: LSD1-CoREST in complex with AW4 and SNAG peptide Method: X-RAY DIFFRACTION / Resolution: 2.82 Å PDB-8f2z: LSD1-CoREST in complex with AW2, short soaking Method: X-RAY DIFFRACTION / Resolution: 3 Å PDB-8f30: LSD1-CoREST in complex with AW2, long soaking Method: X-RAY DIFFRACTION / Resolution: 3.1 Å PDB-8f59: LSD1-CoREST in complex with AW2 and SNAG peptide Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-8f6s: LSD1-CoREST in complex with T105 Method: X-RAY DIFFRACTION / Resolution: 2.91 Å PDB-8fdv: LSD1-CoREST in complex N-formyl FAD and SNAG peptide Method: X-RAY DIFFRACTION / Resolution: 2.95 Å PDB-8fj4: LSD1-CoREST in complex with T108, short soaking Method: X-RAY DIFFRACTION / Resolution: 2.76 Å PDB-8fj7: LSD1-CoREST in complex with T108 and SNAG peptide Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-8fqj: LSD1-CoREST in complex with T14, short soaking Method: X-RAY DIFFRACTION / Resolution: 2.9 Å PDB-8fri: LSD1-CoREST in complex with AW4, short soaking Method: X-RAY DIFFRACTION / Resolution: 2.8 Å PDB-8frq: LSD1-CoREST in complex with T14, long soaking Method: X-RAY DIFFRACTION / Resolution: 2.89 Å PDB-8frv: LSD1-CoREST in complex with T17, short soaking Method: X-RAY DIFFRACTION / Resolution: 2.72 Å PDB-8fsk: LSD1-CoREST in complex with T18, short soaking Method: X-RAY DIFFRACTION / Resolution: 3.13 Å PDB-8gj6: LSD1-CoREST in complex with T16 Method: X-RAY DIFFRACTION / Resolution: 2.77 Å PDB-8ul6: LSD1-CoREST in complex with T16, long soaking Method: X-RAY DIFFRACTION / Resolution: 2.74 Å PDB-8ul8: LSD1-CoREST in complex with T15, short soaking Method: X-RAY DIFFRACTION / Resolution: 2.82 Å PDB-8ulb: LSD1-CoREST in complex with T17, long soaking Method: X-RAY DIFFRACTION / Resolution: 3.41 Å PDB-8ulc: LSD1-CoREST in complex with T15, long soaking Method: X-RAY DIFFRACTION / Resolution: 2.82 Å PDB-8umq: LSD1-CoREST in complex with T18, long soaking Method: X-RAY DIFFRACTION / Resolution: 3.26 Å PDB-8uni: LSD1-CoREST with N-formyl-FAD in complex with H3K4M histone tail Method: X-RAY DIFFRACTION / Resolution: 3.4 Å PDB-8uom: LSD1-CoREST with N-formyl-FAD in complex with H3dimeK4 histone tail Method: X-RAY DIFFRACTION / Resolution: 3.2 Å PDB-9el7: LSD1-CoREST in complex with T105 enantiomer (1R,2S) Method: X-RAY DIFFRACTION / Resolution: 2.87 Å PDB-9el8: LSD1-CoREST in complex with T105 1S2R enantiomer Method: X-RAY DIFFRACTION / Resolution: 2.91 Å PDB-9ela: LSD1-CoREST in complex with T108, long soaking Method: X-RAY DIFFRACTION / Resolution: 2.85 Å
Chemicals	ChemComp, No image ChemComp-SV9: Unknown entry ChemComp, No image ChemComp-XB3: Unknown entry ChemComp, No image ChemComp-XB6: Unknown entry ChemComp, No image ChemComp-XHT: Unknown entry ChemComp, No image ChemComp-XHX: Unknown entry ChemComp-HUF: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate ChemComp, No image ChemComp-XZU: Unknown entry ChemComp, No image ChemComp-XZQ: Unknown entry ChemComp, No image ChemComp-Y0Z: Unknown entry ChemComp, No image ChemComp-Y66: Unknown entry ChemComp, No image ChemComp-Y9K: Unknown entry ChemComp, No image ChemComp-XF6: Unknown entry ChemComp, No image ChemComp-YAF: Unknown entry ChemComp, No image ChemComp-YAO: Unknown entry ChemComp, No image ChemComp-ZSI: Unknown entry ChemComp-K: Unknown entry ChemComp, No image ChemComp-XRK: Unknown entry PDB-1bi4: CATALYTIC DOMAIN OF HIV-1 INTEGRASE
Source	homo sapiens (human)
Keywords	OXIDOREDUCTASE / demethylase / histone / splicing / epigenetics / Histone demethylase / Drug resistance / Covalent inhibitor / OXIDOREDUCTASE/INHIBITOR / OXIDOREDUCTASE-INHIBITOR complex