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Structure paper

TitleStructural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine.
Journal, issue, pagesNat Cardiovasc Res, Vol. 2, Issue 6, Page 587-594, Year 2023
Publish dateMay 4, 2023
AuthorsMichael Lenaeus / Tamer M Gamal El-Din / Lige Tonggu / Ning Zheng / William A Catterall /
External linksNat Cardiovasc Res / PubMed:39185478 / PubMed Central
MethodsEM (single particle)
Resolution3.2 Å
Structure data

28887

8f6p

EMDB-28887, PDB-8f6p:
Rat Cardiac Sodium Channel with Ranolazine Bound
Method: EM (single particle) / Resolution: 3.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-XHO:
(R)-ranolazine

ChemComp-6OU:
[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate / phospholipid*YM

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

Source
  • rattus norvegicus (Norway rat)
  • aequorea victoria (jellyfish)
KeywordsMEMBRANE PROTEIN / Ion Channel Voltage-Gated Ion Channel

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