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Structure paper

TitleThe Molecular Basis for Resistance of E. faecium PBP5 to beta-lactam antibiotics
Journal, issue, pagesTo Be Published
Publish dateNov 10, 2022 (structure data deposition date)
AuthorsHunashal, Y. / Kumar, G.S. / Choy, M.S. / Da Silva Santiago, A. / D'Andrea, E.D. / Schoenle, M.V. / Arthur, M. / Rice, L.B. / Page, R. / Peti, W.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.99 - 3.4 Å
Structure data

PDB-8f3v:
Crystal structure of Penicillin Binding Protein 5 (PBP5) PAPAPAP variant apo form from Enterococcus faecium
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-8f3w:
Crystal structure of Penicillin Binding Protein 5 (PBP5) PAPAPAP variant penicillin bound form from Enterococcus faecium
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-8f3x:
Crystal structure of Penicillin Binding Protein 5 (PBP5) Poly-Gly variant apo form from Enterococcus faecium
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

PDB-8f3y:
Crystal structure of Penicillin Binding Protein 5 (PBP5) Poly-Gly variant penicillin bound form from Enterococcus faecium
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-PNM:
OPEN FORM - PENICILLIN G / antibiotic*YM

Source
  • enterococcus faecium (bacteria)
KeywordsANTIBIOTIC / Penicillin binding / antibiotic resistance / antibiotics

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