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-Structure paper
Title | Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 83, Page 129168-129168, Year 2023 |
Publish date | Nov 2, 2022 (structure data deposition date) |
Authors | Ghosh, A.K. / Shahabi, D. / Kipfmiller, M. / Johnson, M. / Wang, Y.F. / Agniswamy, J. / Amano, M. / Weber, I.T. / Mitsuya, H. |
External links | Bioorg. Med. Chem. Lett. / PubMed:36738797 |
Methods | X-ray diffraction |
Resolution | 1.29 Å |
Structure data | PDB-8f0f: |
Chemicals | ChemComp-NA: ChemComp-CL: ChemComp-GOL: ChemComp-X7H: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE/INHIBITOR / ASPARTIC ACID PROTEASE / HIV-1 protease / Darunavir / a chloroacetamide derivative inhibitor / ANTIVIRAL PROTEIN / HYDROLASE-INHIBITOR complex |