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-Structure paper
Title | Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 16589-16621, Year 2022 |
Publish date | Oct 25, 2022 (structure data deposition date) |
![]() | Hanan, E.J. / Braun, M.G. / Heald, R.A. / MacLeod, C. / Chan, C. / Clausen, S. / Edgar, K.A. / Eigenbrot, C. / Elliott, R. / Endres, N. ...Hanan, E.J. / Braun, M.G. / Heald, R.A. / MacLeod, C. / Chan, C. / Clausen, S. / Edgar, K.A. / Eigenbrot, C. / Elliott, R. / Endres, N. / Friedman, L.S. / Gogol, E. / Gu, X.H. / Thibodeau, R.H. / Jackson, P.S. / Kiefer, J.R. / Knight, J.D. / Nannini, M. / Narukulla, R. / Pace, A. / Pang, J. / Purkey, H.E. / Salphati, L. / Sampath, D. / Schmidt, S. / Sideris, S. / Song, K. / Sujatha-Bhaskar, S. / Ultsch, M. / Wallweber, H. / Xin, J. / Yeap, S. / Young, A. / Zhong, Y. / Staben, S.T. |
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Methods | X-ray diffraction |
Resolution | 1.989 - 2.68 Å |
Structure data | ![]() PDB-8exl: ![]() PDB-8exo: ![]() PDB-8exu: ![]() PDB-8exv: |
Chemicals | ![]() ChemComp-799: ![]() ChemComp-HOH: ![]() ChemComp-X3W: ![]() ChemComp-X3R: ![]() ChemComp-X3N: |
Source |
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![]() | CELL CYCLE / PI3K / drug / inhibitor / cancer / oncology |