+Search query
-Structure paper
Title | "Stapling" scFv for multispecific biotherapeutics of superior properties. |
---|---|
Journal, issue, pages | Mabs, Vol. 15, Page 2195517-2195517, Year 2023 |
Publish date | Aug 3, 2022 (structure data deposition date) |
Authors | Boucher, L.E. / Prinslow, E.G. / Feldkamp, M. / Yi, F. / Nanjunda, R. / Wu, S.J. / Liu, T. / Lacy, E.R. / Jacobs, S. / Kozlyuk, N. ...Boucher, L.E. / Prinslow, E.G. / Feldkamp, M. / Yi, F. / Nanjunda, R. / Wu, S.J. / Liu, T. / Lacy, E.R. / Jacobs, S. / Kozlyuk, N. / Del Rosario, B. / Wu, B. / Aquino, P. / Davidson, R.C. / Heyne, S. / Mazzanti, N. / Testa, J. / Diem, M.D. / Gorre, E. / Mahan, A. / Nanda, H. / Gunawardena, H.P. / Gervais, A. / Armstrong, A.A. / Teplyakov, A. / Huang, C. / Zwolak, A. / Chowdhury, P. / Cheung, W.C. / Luo, J. |
External links | Mabs / PubMed:37074212 |
Methods | X-ray diffraction |
Resolution | 1.509 - 2.68 Å |
Structure data | PDB-8dy0: PDB-8dy1: PDB-8dy2: PDB-8dy3: PDB-8dy4: PDB-8dy5: |
Chemicals | ChemComp-HOH: ChemComp-SO4: ChemComp-CL: ChemComp-CA: ChemComp-MG: |
Source |
|
Keywords | IMMUNE SYSTEM / scFv / stapled scFv / spFv / germline scFv / single chain Fv / scFv stabilizations / antibody / antibody antigen complex |