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-Structure paper
Title | Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem., Vol. 74, Page 117034-117034, Year 2022 |
Publish date | Jun 9, 2022 (structure data deposition date) |
Authors | Zhang, W. / Wu, M. / Vadlakonda, S. / Juarez, L. / Cheng, X. / Muppa, S. / Chintareddy, V. / Vogeti, L. / Kellogg-Yelder, D. / Williams, J. ...Zhang, W. / Wu, M. / Vadlakonda, S. / Juarez, L. / Cheng, X. / Muppa, S. / Chintareddy, V. / Vogeti, L. / Kellogg-Yelder, D. / Williams, J. / Polach, K. / Chen, X. / Raman, K. / Babu, Y.S. / Kotian, P. |
External links | Bioorg. Med. Chem. / PubMed:36272185 |
Methods | X-ray diffraction |
Resolution | 1.986 - 2.214 Å |
Structure data | PDB-8d95: PDB-8dea: PDB-8dg6: |
Chemicals | ChemComp-QIE: ChemComp-HOH: ChemComp-R7X: ChemComp-GOL: ChemComp-S7X: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / serine protease inhibitor complex / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR complex |