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-Structure paper
Title | Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 10251-10284, Year 2022 |
Publish date | Jun 6, 2022 (structure data deposition date) |
![]() | Szychowski, J. / Papp, R. / Dietrich, E. / Liu, B. / Vallee, F. / Leclaire, M.E. / Fourtounis, J. / Martino, G. / Perryman, A.L. / Pau, V. ...Szychowski, J. / Papp, R. / Dietrich, E. / Liu, B. / Vallee, F. / Leclaire, M.E. / Fourtounis, J. / Martino, G. / Perryman, A.L. / Pau, V. / Yin, S.Y. / Mader, P. / Roulston, A. / Truchon, J.F. / Marshall, C.G. / Diallo, M. / Duffy, N.M. / Stocco, R. / Godbout, C. / Bonneau-Fortin, A. / Kryczka, R. / Bhaskaran, V. / Mao, D. / Orlicky, S. / Beaulieu, P. / Turcotte, P. / Kurinov, I. / Sicheri, F. / Mamane, Y. / Gallant, M. / Black, W.C. |
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Methods | X-ray diffraction |
Resolution | 2.15 - 2.49 Å |
Structure data | ![]() PDB-8d6c: ![]() PDB-8d6d: ![]() PDB-8d6e: ![]() PDB-8d6f: |
Chemicals | ![]() ChemComp-EDO: ![]() ChemComp-SO4: ![]() ChemComp-QGR: ![]() ChemComp-GOL: ![]() ChemComp-HOH: ![]() ChemComp-QGY: ![]() ChemComp-QGI: ![]() ChemComp-QG5: |
Source |
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![]() | SIGNALING PROTEIN / Transferase/Inhibitor / Kinase Inhibitor complex / Transferase-Inhibitor complex |