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Title | Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. |
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Journal, issue, pages | Rsc Chem Biol, Vol. 4, Page 334-343, Year 2023 |
Publish date | May 18, 2022 (structure data deposition date) |
![]() | Zhao, X.Z. / Wang, W. / Lountos, G.T. / Kiselev, E. / Tropea, J.E. / Needle, D. / Pommier, Y. / Burke Jr., T.R. |
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Methods | X-ray diffraction |
Resolution | 1.65 - 1.811 Å |
Structure data | ![]() PDB-8cvq: ![]() PDB-8cw2: |
Chemicals | ![]() ChemComp-OYH: ![]() ChemComp-MPO: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-OYR: ![]() ChemComp-DMS: |
Source |
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![]() | HYDROLASE / phosphodiesterase / DNA BINDING PROTEIN |