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-Structure paper
Title | Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently) |
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Journal, issue, pages | To Be Published |
Publish date | Mar 4, 2023 (structure data deposition date) |
![]() | Kirkman, T.J. / Dias, M.V.B. / Coyne, A.G. |
![]() | Search PubMed |
Methods | X-ray diffraction |
Resolution | 1.75 - 2 Å |
Structure data | ![]() PDB-8cq8: ![]() PDB-8cq9: ![]() PDB-8cqa: |
Chemicals | ![]()
ChemComp-VFF: ![]() ChemComp-MES: ![]() ChemComp-NDP: ![]() ChemComp-CO: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]()
ChemComp-VFU: ![]()
ChemComp-VF6: |
Source |
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![]() | BIOSYNTHETIC PROTEIN / Dihydrofolate reductase Mycobacterium tuberculosis |