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TitleModulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Journal, issue, pagesChem Sci, Vol. 14, Page 7524-7536, Year 2023
Publish dateJan 30, 2023 (structure data deposition date)
AuthorsShaw, D.J. / Waters, L.C. / Strong, S.L. / Schulze, M.E.D. / Greetham, G.M. / Towrie, M. / Parker, A.W. / Prosser, C.E. / Henry, A.J. / Lawson, A.D.G. ...Shaw, D.J. / Waters, L.C. / Strong, S.L. / Schulze, M.E.D. / Greetham, G.M. / Towrie, M. / Parker, A.W. / Prosser, C.E. / Henry, A.J. / Lawson, A.D.G. / Carr, M.D. / Taylor, R.J. / Hunt, N.T. / Muskett, F.W.
External linksChem Sci / PubMed:37449080
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-8cdg:
Crystal structure of human IL-17A cytokine in complex with macrocycle
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-UTF:
(9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid

Source
  • homo sapiens (human)
KeywordsCYTOKINE / inhibitor / complex / macrocycle

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