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-Structure paper
Title | Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 14, Page 156-162, Year 2023 |
Publish date | Sep 25, 2022 (structure data deposition date) |
![]() | Torrente, E. / Fodale, V. / Ciammaichella, A. / Ferrigno, F. / Ontoria, J.M. / Ponzi, S. / Rossetti, I. / Sferrazza, A. / Amaudrut, J. / Missineo, A. ...Torrente, E. / Fodale, V. / Ciammaichella, A. / Ferrigno, F. / Ontoria, J.M. / Ponzi, S. / Rossetti, I. / Sferrazza, A. / Amaudrut, J. / Missineo, A. / Esposito, S. / Palombo, S. / Nibbio, M. / Cerretani, M. / Bisbocci, M. / Cellucci, A. / di Marco, A. / Alli, C. / Pucci, V. / Toniatti, C. / Petrocchi, A. |
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Methods | X-ray diffraction |
Resolution | 1.83 - 2.24 Å |
Structure data | ![]() PDB-8b5y: ![]() PDB-8cbh: |
Chemicals | ![]() ChemComp-P8O: ![]() ChemComp-FMT: ![]() ChemComp-HOH: ![]() ChemComp-U70: |
Source |
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![]() | SIGNALING PROTEIN / SHP2 / allosteric inhibitors / imidazopyrazine / oncology |