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TitleBiochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the alpha-Helix Pocket on TEAD.
Journal, issue, pagesAcs Chem. Biol., Vol. 18, Page 643-651, Year 2023
Publish dateDec 20, 2022 (structure data deposition date)
AuthorsMesrouze, Y. / Gubler, H. / Villard, F. / Boesch, R. / Ottl, J. / Kallen, J. / Reid, P.C. / Scheufler, C. / Marzinzik, A.L. / Chene, P.
External linksAcs Chem. Biol. / PubMed:36825662
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-8c17:
Crystal structure of TEAD4 in complex with peptide 1
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-MYR:
MYRISTIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / Complex / Inhibitor

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