EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
ジャーナル・号・ページ	J. Med. Chem., Vol. 67, Page 15521-15536, Year 2024
掲載日	2022年12月20日 (構造データの登録日)
著者	Stockwell, S.R. / Scott, D.E. / Fischer, G. / Guarino, E. / Rooney, T.P.C. / Feng, T.S. / Moschetti, T. / Srinivasan, R. / Alza, E. / Asteian, A. ...Stockwell, S.R. / Scott, D.E. / Fischer, G. / Guarino, E. / Rooney, T.P.C. / Feng, T.S. / Moschetti, T. / Srinivasan, R. / Alza, E. / Asteian, A. / Dagostin, C. / Alcaide, A. / Rocaboy, M. / Blaszczyk, B. / Higueruelo, A. / Wang, X. / Rossmann, M. / Perrior, T.R. / Blundell, T.L. / Spring, D.R. / McKenzie, G. / Abell, C. / Skidmore, J. / Venkitaraman, A.R. / Hyvonen, M.
リンク	J. Med. Chem. / PubMed:39190548
手法	X線回折
解像度	1.924 - 2.84 Å
構造データ	PDB-8c14: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-8c15: Aurora A kinase in complex with TPX2-inhibitor 3 手法: X-RAY DIFFRACTION / 解像度: 2.41 Å PDB-8c1d: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 2.115 Å PDB-8c1e: Aurora A kinase in complex with TPX2-inhibitor 9 手法: X-RAY DIFFRACTION / 解像度: 2.798 Å PDB-8c1f: Aurora A kinase in complex with TPX2-inhibitor 6 手法: X-RAY DIFFRACTION / 解像度: 1.924 Å PDB-8c1g: Aurora A kinase in complex with TPX2-inhibitor 7 手法: X-RAY DIFFRACTION / 解像度: 1.96 Å PDB-8c1h: Aurora A kinase in complex with TPX2-inhibitor 8 手法: X-RAY DIFFRACTION / 解像度: 2.233 Å PDB-8c1i: Aurora A kinase in complex with TPX2-inhibitor 10 手法: X-RAY DIFFRACTION / 解像度: 2.81 Å PDB-8c1k: Aurora A kinase in complex with TPX2-inhibitor CAM2602 手法: X-RAY DIFFRACTION / 解像度: 2.43 Å PDB-8c1m: Aurora A kinase in complex with TPX2-inhibitor 2 手法: X-RAY DIFFRACTION / 解像度: 2.84 Å
化合物	ChemComp-MG: Unknown entry ChemComp-SO4: SULFATE ION ChemComp-CL: Unknown entry ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, 沈殿剤YM ChemComp-ACT: ACETATE ION ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP, エネルギー貯蔵分子YM ChemComp-T5L: (1~{R},2~{R})-cyclohexane-1,2-dicarboxylic acid ChemComp-GOL: GLYCEROL ChemComp-T0L: 4-(4-chloranyl-3-cyano-phenyl)-1~{H}-indole-6-carboxylic acid ChemComp-HOH: WATER ChemComp-T4C: 4-(4-chlorophenyl)-1~{H}-indole-6-carboxylic acid ChemComp-T2F: 4-(4-chlorophenyl)-7-methyl-1~{H}-indole-6-carboxylic acid ChemComp-T0X: 4-(4-chloranyl-3-cyano-phenyl)-7-methyl-1~{H}-indole-6-carboxylic acid ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子YM ChemComp-T2O: 4-(4-chlorophenyl)-~{N}-cyclopropylsulfonyl-7-methyl-1~{H}-indole-6-carboxamide ChemComp-T3I: 4-(4-chlorophenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide ChemComp-T3U: 4-(4-chloranyl-3-pyrazin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide ChemComp-T1L: 4-(4-chloranyl-3-pyridin-2-yloxy-phenyl)-~{N}-cyclopropylsulfonyl-7-methyl-1~{H}-indole-6-carboxamide ChemComp-T4O: 4-(4-chloranyl-3-pyridin-2-yloxy-phenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide ChemComp-T4X*: 3-oxidanyl-5-[4-(trifluoromethyloxy)phenyl]benzoic acid
由来	homo sapiens (ヒト)
キーワード	CELL CYCLE / protein-ligand complex / kinase / protein-protein interaction inhibitor / TPX2