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-Structure paper
Title | Shifting the selectivity of pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors towards the salt-inducible kinase (SIK) subfamily. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 254, Page 115347-115347, Year 2023 |
Publish date | Nov 2, 2022 (structure data deposition date) |
![]() | Rak, M. / Tesch, R. / Berger, L.M. / Shevchenko, E. / Raab, M. / Tjaden, A. / Zhubi, R. / Balourdas, D.I. / Joerger, A.C. / Poso, A. ...Rak, M. / Tesch, R. / Berger, L.M. / Shevchenko, E. / Raab, M. / Tjaden, A. / Zhubi, R. / Balourdas, D.I. / Joerger, A.C. / Poso, A. / Kramer, A. / Elson, L. / Lucic, A. / Kronenberger, T. / Hanke, T. / Strebhardt, K. / Sanhaji, M. / Knapp, S. |
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Methods | X-ray diffraction |
Resolution | 1.5 - 1.72 Å |
Structure data | ![]() PDB-8bin: ![]() PDB-8bio: ![]() PDB-8bzi: |
Chemicals | ![]() ChemComp-EDO: ![]() ChemComp-QRR: ![]() ChemComp-HOH: ![]() ChemComp-QRD: ![]() ChemComp-SJL: |
Source |
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![]() | TRANSFERASE / EPHA2 / ECK / Typ I Inhibitor / selective kinase inhibitors / structure-based drug design |