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Structure paper

TitleMolecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.
Journal, issue, pagesBiorxiv, Year 2024
Publish dateNov 29, 2022 (structure data deposition date)
AuthorsKatz, L.S. / Visser, E.J. / Plitzko, K.F. / Pennings, M. / Cossar, P.J. / Tse, I.L. / Kaiser, M. / Brunsveld, L. / Scott, D.K. / Ottmann, C.
External linksBiorxiv / PubMed:38405965
MethodsX-ray diffraction
Resolution1.6 - 2.1 Å
Structure data

PDB-8btq:
Small molecule stabilizer for 14-3-3/ChREBP (Cmd1-soaking)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-8bwe:
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 43)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8bwh:
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-8c1y:
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 30)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-OQE:
[2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-UH9:
Unknown entry


ChemComp, No image

ChemComp-XSL:
Unknown entry


ChemComp, No image

ChemComp-U0U:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / 14-3-3 / ChREBP / stabilization

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