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Title | The Identification of Potent, Selective, and Brain Penetrant PI5P4K gamma Inhibitors as In Vivo-Ready Tool Molecules. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 804-821, Year 2023 |
Publish date | Nov 18, 2022 (structure data deposition date) |
Authors | Rooney, T.P.C. / Aldred, G.G. / Boffey, H.K. / Willems, H.M.G. / Edwards, S. / Chawner, S.J. / Scott, D.E. / Green, C. / Winpenny, D. / Skidmore, J. ...Rooney, T.P.C. / Aldred, G.G. / Boffey, H.K. / Willems, H.M.G. / Edwards, S. / Chawner, S.J. / Scott, D.E. / Green, C. / Winpenny, D. / Skidmore, J. / Clarke, J.H. / Andrews, S.P. |
External links | J. Med. Chem. / PubMed:36516442 |
Methods | X-ray diffraction |
Resolution | 2.42 Å |
Structure data | PDB-8bq4: |
Chemicals | ChemComp-QZR: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / LIPID KINASE / ATP-COMPETITIVE INHIBITOR / PHOSPHATIDYLINOSITOL 5-PHOSPHATE |