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Structure paper

TitleBAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 16420-16431, Year 2022
Publish dateNov 18, 2022 (structure data deposition date)
AuthorsMeibom, D. / Micus, S. / Andreevski, A.L. / Anlauf, S. / Bogner, P. / von Buehler, C.J. / Dieskau, A.P. / Dreher, J. / Eitner, F. / Fliegner, D. ...Meibom, D. / Micus, S. / Andreevski, A.L. / Anlauf, S. / Bogner, P. / von Buehler, C.J. / Dieskau, A.P. / Dreher, J. / Eitner, F. / Fliegner, D. / Follmann, M. / Gericke, K.M. / Maassen, S. / Meyer, J. / Schlemmer, K.H. / Steuber, H. / Tersteegen, A. / Wunder, F.
External linksJ. Med. Chem. / PubMed:36475653
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-8bpy:
X-RAY STRUCTURE OF PDE9A IN COMPLEX WITH Inhibitor 13A
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-R4I:
(8~{S})-6-[2-(2,3-dihydroindol-1-yl)-2-oxidanylidene-ethyl]-4-(4-methylphenyl)-2-oxidanylidene-8-propyl-1,5,7,8-tetrahydro-1,6-naphthyridine-3-carbonitrile

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PDE9A / inhibitor

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