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TitleA Tailored Strategy to Crosslink the Aspartate Transcarbamoylase Domain of the Multienzymatic Protein CAD.
Journal, issue, pagesMolecules, Vol. 28, Year 2023
Publish dateNov 16, 2022 (structure data deposition date)
AuthorsDel Cano-Ochoa, F. / Rubio-Del-Campo, A. / Ramon-Maiques, S.
External linksMolecules / PubMed:36677714
MethodsX-ray diffraction
Resolution1.58 - 2.03 Å
Structure data

PDB-8bpl:
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like bound to carbamoyl phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-8bps:
Aspartate transcarbamoylase mutant (N2045C, R2238C) from Chaetomium thermophilum CAD-like in apo form
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-CP:
PHOSPHORIC ACID MONO(FORMAMIDE)ESTER

ChemComp-GOL:
GLYCEROL

ChemComp-SIN:
SUCCINIC ACID

ChemComp-HOH:
WATER

Source
  • thermochaetoides thermophila (fungus)
KeywordsTRANSFERASE / Nucleotide metabolism / de novo pyrimidine synthesis / CAD / cysteine / disulfide bridge / protein stability / crosslinking / succinate / multienzymatic protein

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