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TitleExploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.
Journal, issue, pagesInt J Mol Sci, Vol. 23, Year 2022
Publish dateOct 18, 2022 (structure data deposition date)
AuthorsPalomba, T. / Tassone, G. / Vacca, C. / Bartalucci, M. / Valeri, A. / Pozzi, C. / Cross, S. / Siragusa, L. / Desantis, J.
External linksInt J Mol Sci / PubMed:36430693
MethodsX-ray diffraction
Resolution3.05 - 3.2 Å
Structure data

PDB-8bd8:
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 8
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-8bd9:
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 10
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-8bdy:
Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 9
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Chemicals

ChemComp-QCU:
1,3-dimethylbenzimidazol-2-one

ChemComp-ZN:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / TRIM33 alpha / PHD-Bromo domain / complex

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