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TitleAn ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin.
Journal, issue, pagesCommun Chem, Vol. 7, Page 81-81, Year 2024
Publish dateOct 17, 2022 (structure data deposition date)
AuthorsHill, J.A. / Nyathi, Y. / Horrell, S. / von Stetten, D. / Axford, D. / Owen, R.L. / Beddard, G.S. / Pearson, A.R. / Ginn, H.M. / Yorke, B.A.
External linksCommun Chem / PubMed:38600176
MethodsX-ray diffraction
Resolution2 - 2.1 Å
Structure data

PDB-8bd0:
Human Gamma-D crystallin R36S mutant with DTT-Cystein Protein modification
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8bpi:
Human Gamma-D crystallin R36S mutant after UV illumination
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-8q3l:
Human Gamma-D Crystallin R36S fresh serial crystallographic structure
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / chemical modification / oxidisation / eye lens protein / UV exposure

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