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Title | Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 15208-15226, Year 2022 |
Publish date | Sep 28, 2022 (structure data deposition date) |
Authors | Miller, M. / Rossetti, T. / Ferreira, J. / Ghanem, L. / Balbach, M. / Kaur, N. / Levin, L.R. / Buck, J. / Kehr, M. / Coquille, S. ...Miller, M. / Rossetti, T. / Ferreira, J. / Ghanem, L. / Balbach, M. / Kaur, N. / Levin, L.R. / Buck, J. / Kehr, M. / Coquille, S. / van den Heuvel, J. / Steegborn, C. / Fushimi, M. / Finkin-Groner, E. / Myers, R.W. / Kargman, S. / Liverton, N.J. / Huggins, D.J. / Meinke, P.T. |
External links | J. Med. Chem. / PubMed:36346696 |
Methods | X-ray diffraction |
Resolution | 1.82 Å |
Structure data | PDB-8b75: |
Chemicals | ChemComp-PJU: ChemComp-HOH: |
Source |
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Keywords | SIGNALING PROTEIN / SOLUBLE ADENYLYL CYCLASE / ADCY10 / SIGNALING ENZYME / CLASS III CYCLASE |