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-Structure paper
Title | Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 13629-13644, Year 2022 |
Publish date | Jun 8, 2022 (structure data deposition date) |
Authors | Davie, R.L. / Edwards, H.J. / Evans, D.M. / Hodgson, S.T. / Stocks, M.J. / Smith, A.J. / Rushbrooke, L.J. / Pethen, S.J. / Roe, M.B. / Clark, D.E. ...Davie, R.L. / Edwards, H.J. / Evans, D.M. / Hodgson, S.T. / Stocks, M.J. / Smith, A.J. / Rushbrooke, L.J. / Pethen, S.J. / Roe, M.B. / Clark, D.E. / McEwan, P.A. / Hampton, S.L. |
External links | J. Med. Chem. / PubMed:36251573 |
Methods | X-ray diffraction |
Resolution | 1.801 Å |
Structure data | PDB-8a3q: |
Chemicals |
ChemComp-UNL: ChemComp-MES: ChemComp-NAG: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Inhibitor / Complex / serine-like protease |