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Structure paper

TitleDiscovery of Nanomolar-Affinity Pharmacological Chaperones Stabilizing the Oncogenic p53 Mutant Y220C.
Journal, issue, pagesAcs Pharmacol Transl Sci, Vol. 5, Page 1169-1180, Year 2022
Publish dateJun 6, 2022 (structure data deposition date)
AuthorsStephenson Clarke, J.R. / Douglas, L.R. / Duriez, P.J. / Balourdas, D.I. / Joerger, A.C. / Khadiullina, R. / Bulatov, E. / Baud, M.G.J.
External linksAcs Pharmacol Transl Sci / PubMed:36407959
MethodsX-ray diffraction
Resolution1.46 - 1.47 Å
Structure data

PDB-8a31:
p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC694
Method: X-RAY DIFFRACTION / Resolution: 1.46 Å

PDB-8a32:
p53 cancer mutant Y220C in complex with iodophenol-based small-molecule stabilizer JC769
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

Chemicals

ChemComp-KV0:
4-(3-fluoranylpyrrol-1-yl)-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-KVA:
4-[3,4-bis(fluoranyl)pyrrol-1-yl]-3,5-bis(iodanyl)-2-oxidanyl-benzoic acid

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / tumor suppressor p53 / cancer mutant / drug discovery / small-molecule stabilizer

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