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-Structure paper
Title | Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 2386-2395, Year 2023 |
Publish date | May 19, 2022 (structure data deposition date) |
![]() | Blum, A. / Dorsch, D. / Linde, N. / Brandstetter, S. / Buchstaller, H.P. / Busch, M. / Glaser, N. / Gradler, U. / Ruff, A. / Petersson, C. ...Blum, A. / Dorsch, D. / Linde, N. / Brandstetter, S. / Buchstaller, H.P. / Busch, M. / Glaser, N. / Gradler, U. / Ruff, A. / Petersson, C. / Schieferstein, H. / Sherbetjian, E. / Esdar, C. |
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Methods | X-ray diffraction |
Resolution | 2.119 - 3.09 Å |
Structure data | ![]() PDB-7zw8: ![]() PDB-7zy6: |
Chemicals | ![]() ChemComp-K3R: ![]() ChemComp-HOH: ![]() ChemComp-KCI: |
Source |
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![]() | TRANSFERASE / TYROSINE-PROTEIN KINASE / cKIT |