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-Structure paper
Title | A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. |
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Journal, issue, pages | Iscience, Vol. 26, Page 107919-107919, Year 2023 |
Publish date | Apr 12, 2022 (structure data deposition date) |
![]() | Guay, K.P. / Ibba, R. / Kiappes, J.L. / Vasiljevic, S. / Boni, F. / De Benedictis, M. / Zeni, I. / Le Cornu, J.D. / Hensen, M. / Chandran, A.V. ...Guay, K.P. / Ibba, R. / Kiappes, J.L. / Vasiljevic, S. / Boni, F. / De Benedictis, M. / Zeni, I. / Le Cornu, J.D. / Hensen, M. / Chandran, A.V. / Kantsadi, A.L. / Caputo, A.T. / Blanco Capurro, J.I. / Bayo, Y. / Hill, J.C. / Hudson, K. / Lia, A. / Brun, J. / Withers, S.G. / Marti, M. / Biasini, E. / Santino, A. / De Rosa, M. / Milani, M. / Modenutti, C.P. / Hebert, D.N. / Zitzmann, N. / Roversi, P. |
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Methods | X-ray diffraction |
Resolution | 1.649 - 2.049 Å |
Structure data | ![]() PDB-7zkc: ![]() PDB-7zll: ![]() PDB-7zlu: |
Chemicals | ![]() ChemComp-CA: ![]() ChemComp-HOH: ![]() ChemComp-JM3: ![]() ChemComp-NAG: ![]() ChemComp-MAN: ![]() ChemComp-U2F: ![]() ChemComp-PDO: |
Source |
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![]() | TRANSFERASE / glycoprotein / misfolding / endoplasmic reticulum. UDP-glucose / GT24 / endoplasmic reticulum / 5-[(morpholin-4-yl)methyl]quinolin-8-ol / UDP-2-deoxy-2-fluoro-D-glucose |