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-Structure paper
Title | Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. |
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Journal, issue, pages | Sci Adv, Vol. 8, Page eabm5563-eabm5563, Year 2022 |
Publish date | Apr 7, 2022 (structure data deposition date) |
Authors | Kinnebrew, M. / Woolley, R.E. / Ansell, T.B. / Byrne, E.F.X. / Frigui, S. / Luchetti, G. / Sircar, R. / Nachtergaele, S. / Mydock-McGrane, L. / Krishnan, K. ...Kinnebrew, M. / Woolley, R.E. / Ansell, T.B. / Byrne, E.F.X. / Frigui, S. / Luchetti, G. / Sircar, R. / Nachtergaele, S. / Mydock-McGrane, L. / Krishnan, K. / Newstead, S. / Sansom, M.S.P. / Covey, D.F. / Siebold, C. / Rohatgi, R. |
External links | Sci Adv / PubMed:35658032 |
Methods | X-ray diffraction |
Resolution | 3 Å |
Structure data | PDB-7zi0: |
Chemicals | ChemComp-V0S: ChemComp-CLR: ChemComp-NAG: ChemComp-NA: ChemComp-MPG: |
Source |
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Keywords | MEMBRANE PROTEIN / Class F G protein coupled receptor / Hedgehog signalling / oncoprotein / drug target / signal transduction / morphogen / cholesterol |