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Structure paper

TitleStructural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
Journal, issue, pagesNucleic Acids Res., Vol. 51, Page 7649-7665, Year 2023
Publish dateAug 21, 2022 (structure data deposition date)
AuthorsYang, X. / Wang, J. / Li, S. / Li, X. / Gong, J. / Yan, Z. / Zhou, H. / Wu, C. / Liu, X.
External linksNucleic Acids Res. / PubMed:37334830
MethodsX-ray diffraction
Resolution2.18 - 2.5 Å
Structure data

PDB-7yw2:
Crystal structure of tRNA 2'-phosphotransferase from Mus musculus
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-7yw3:
Crystal structure of tRNA 2'-phosphotransferase from Homo sapiens
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7yw4:
Crystal structure of tRNA 2'-phosphotransferase from Saccharomyces cerevisiae
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-HQG:
[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GLY:
GLYCINE

ChemComp-SOR:
sorbitol

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-TAR:
D(-)-TARTARIC ACID

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSFERASE / tRNA 2'-phosphotransferase

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