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TitleFarrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer.
Journal, issue, pagesNat Commun, Vol. 14, Page 1838-1838, Year 2023
Publish dateAug 18, 2022 (structure data deposition date)
AuthorsZhang, W. / Wang, M. / Song, Z. / Fu, Q. / Chen, J. / Gao, S. / Sun, X. / Yang, G. / Zhang, Q. / Yang, J. ...Zhang, W. / Wang, M. / Song, Z. / Fu, Q. / Chen, J. / Gao, S. / Sun, X. / Yang, G. / Zhang, Q. / Yang, J. / Tang, H. / Wang, H. / Kou, X. / Mao, Z. / Xu, X. / Jiang, Y.
External linksNat Commun / PubMed:37012254
MethodsX-ray diffraction
Resolution1.58 Å
Structure data

PDB-7yv4:
Crystal structure of human UCHL3 in complex with Farrerol
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

Chemicals

ChemComp-JXY:
(2~{S})-2-(4-hydroxyphenyl)-6,8-dimethyl-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Activator / Complex / Ubiquitinase

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