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-Structure paper
| Title | Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets. |
|---|---|
| Journal, issue, pages | J. Am. Chem. Soc., Vol. 145, Page 24035-24051, Year 2023 |
| Publish date | Aug 18, 2022 (structure data deposition date) |
 Authors | Ohta, A. / Tanada, M. / Shinohara, S. / Morita, Y. / Nakano, K. / Yamagishi, Y. / Takano, R. / Kariyuki, S. / Iida, T. / Matsuo, A. ...Ohta, A. / Tanada, M. / Shinohara, S. / Morita, Y. / Nakano, K. / Yamagishi, Y. / Takano, R. / Kariyuki, S. / Iida, T. / Matsuo, A. / Ozeki, K. / Emura, T. / Sakurai, Y. / Takano, K. / Higashida, A. / Kojima, M. / Muraoka, T. / Takeyama, R. / Kato, T. / Kimura, K. / Ogawa, K. / Ohara, K. / Tanaka, S. / Kikuchi, Y. / Hisada, N. / Hayashi, R. / Nishimura, Y. / Nomura, K. / Tachibana, T. / Irie, M. / Kawada, H. / Torizawa, T. / Murao, N. / Kotake, T. / Tanaka, M. / Ishikawa, S. / Miyake, T. / Tamiya, M. / Arai, M. / Chiyoda, A. / Akai, S. / Sase, H. / Kuramoto, S. / Ito, T. / Shiraishi, T. / Kojima, T. / Iikura, H. |
 External links | J. Am. Chem. Soc. / PubMed:37874670 |
| Methods | X-ray diffraction |
| Resolution | 1.454 - 1.878 Å |
| Structure data |  PDB-7yuz:  PDB-7yv1: |
| Chemicals |  ChemComp-GDP:  ChemComp-MG:  ChemComp-IOD:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN/INHIBITOR / ONCOLOGY / SIGNALING PROTEIN-INHIBITOR COMPLEX / SIGNALING PROTEIN / K-RAS / CYCLIC PEPTIDE |
homo sapiens (human)