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-Structure paper
Title | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 144, Page 20332-20341, Year 2022 |
Publish date | Jun 3, 2022 (structure data deposition date) |
![]() | Vinogradov, A.A. / Zhang, Y. / Hamada, K. / Chang, J.S. / Okada, C. / Nishimura, H. / Terasaka, N. / Goto, Y. / Ogata, K. / Sengoku, T. ...Vinogradov, A.A. / Zhang, Y. / Hamada, K. / Chang, J.S. / Okada, C. / Nishimura, H. / Terasaka, N. / Goto, Y. / Ogata, K. / Sengoku, T. / Onaka, H. / Suga, H. |
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Methods | X-ray diffraction |
Resolution | 2.09 - 2.26 Å |
Structure data | ![]() PDB-7xzq: ![]() PDB-7xzr: |
Chemicals | ![]() ChemComp-BU1: ![]() ChemComp-HOH: ![]() ChemComp-ANP: ![]() ChemComp-MG: ![]() ChemComp-SO4: ![]() ChemComp-PGE: |
Source |
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![]() | SIGNALING PROTEIN/INHIBITOR / ripp / thiopeptide / kinase inhibition / complex / SIGNALING PROTEIN / SIGNALING PROTEIN-INHIBITOR complex |