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TitleMolecular basis for anti-insomnia drug design from structure of lemborexant-bound orexin 2 receptor.
Journal, issue, pagesStructure, Vol. 30, Page 1582-1589.e4, Year 2022
Publish dateMay 11, 2022 (structure data deposition date)
AuthorsAsada, H. / Im, D. / Hotta, Y. / Yasuda, S. / Murata, T. / Suno, R. / Iwata, S.
External linksStructure / PubMed:36417909
MethodsX-ray diffraction
Resolution2.89 Å
Structure data

PDB-7xrr:
Crystal structure of the human OX2R bound to the insomnia drug lemborexant.
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-NRK:
(1~{R},2~{S})-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-~{N}-(5-fluoranylpyridin-2-yl)-2-(3-fluorophenyl)cyclopropane-1-carboxamide / medication, antagonist*YM

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / GPCR / insomnia drug

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