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Title | Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. |
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Journal, issue, pages | Sci Adv, Vol. 8, Page eabo0789-eabo0789, Year 2022 |
Publish date | Sep 27, 2021 (structure data deposition date) |
![]() | Zhang, X.W. / Feng, N. / Liu, Y.C. / Guo, Q. / Wang, J.K. / Bai, Y.Z. / Ye, X.M. / Yang, Z. / Yang, H. / Liu, Y. ...Zhang, X.W. / Feng, N. / Liu, Y.C. / Guo, Q. / Wang, J.K. / Bai, Y.Z. / Ye, X.M. / Yang, Z. / Yang, H. / Liu, Y. / Yang, M.M. / Wang, Y.H. / Shi, X.M. / Liu, D. / Tu, P.F. / Zeng, K.W. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.3 - 2.35 Å |
Structure data | ![]() PDB-7vij: ![]() PDB-7xpy: |
Chemicals | ![]() ChemComp-HOH: ![]() ChemComp-EIB: |
Source |
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![]() | HYDROLASE / protein degradation / Ubiquitin-specific protease / Inhibitor |