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TitleDiscovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.
Journal, issue, pagesJ. Med. Chem., Vol. 65, Page 6325-6337, Year 2022
Publish dateMar 17, 2022 (structure data deposition date)
AuthorsWang, Z. / Wang, J. / Wang, Y. / Xiang, S. / Song, X. / Tu, Z. / Zhou, Y. / Zhang, Z.M. / Zhang, Z. / Ding, K. / Lu, X.
External linksJ. Med. Chem. / PubMed:35426680
MethodsX-ray diffraction
Resolution3.00118200625 Å
Structure data

PDB-7xaf:
The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide
Method: X-RAY DIFFRACTION / Resolution: 3.00118200625 Å

Chemicals

ChemComp-FKT:
4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / TrkA / Transferase Inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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