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TitleMechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth.
Journal, issue, pagesAcs Chem. Biol., Vol. 18, Page 1335-1350, Year 2023
Publish dateMar 15, 2022 (structure data deposition date)
AuthorsCho, C.C. / Lin, C.J. / Huang, H.H. / Yang, W.Z. / Fei, C.Y. / Lin, H.Y. / Lee, M.S. / Yuan, H.S.
External linksAcs Chem. Biol. / PubMed:37188336
MethodsX-ray diffraction
Resolution3.08 Å
Structure data

PDB-7x9d:
DNMT3B in complex with harmine
Method: X-RAY DIFFRACTION / Resolution: 3.08 Å

Chemicals

ChemComp-HRM:
7-METHOXY-1-METHYL-9H-BETA-CARBOLINE / inhibitor, alkaloid*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Inhibitor / Comple / Methyltransferase

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