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Structure paper

TitleChemically targeting the redox switch in AP1 transcription factor Delta FOSB.
Journal, issue, pagesNucleic Acids Res., Vol. 50, Page 9548-9567, Year 2022
Publish dateMar 16, 2022 (structure data deposition date)
AuthorsKumar, A. / Aglyamova, G. / Yim, Y.Y. / Bailey, A.O. / Lynch, H.M. / Powell, R.T. / Nguyen, N.D. / Rosenthal, Z. / Zhao, W.N. / Li, Y. ...Kumar, A. / Aglyamova, G. / Yim, Y.Y. / Bailey, A.O. / Lynch, H.M. / Powell, R.T. / Nguyen, N.D. / Rosenthal, Z. / Zhao, W.N. / Li, Y. / Chen, J. / Fan, S. / Lee, H. / Russell, W.K. / Stephan, C. / Robison, A.J. / Haggarty, S.J. / Nestler, E.J. / Zhou, J. / Machius, M. / Rudenko, G.
External linksNucleic Acids Res. / PubMed:36039764
MethodsX-ray diffraction
Resolution1.94 - 3.21 Å
Structure data

PDB-7ucc:
Transcription factor FosB/JunD bZIP domain in the reduced form
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

PDB-7ucd:
Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-EOH:
ETHANOL

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MV0:
7-acetyl-4-methoxy-1-benzofuran-3(2H)-one

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / FosB / JunD / redox switch / redox sensor / transcription factor

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