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TitleLigand dependent interaction between PC-TP and PPAR delta mitigates diet-induced hepatic steatosis in male mice.
Journal, issue, pagesNat Commun, Vol. 14, Page 2748-2748, Year 2023
Publish dateMar 10, 2022 (structure data deposition date)
AuthorsDruzak, S.A. / Tardelli, M. / Mays, S.G. / El Bejjani, M. / Mo, X. / Maner-Smith, K.M. / Bowen, T. / Cato, M.L. / Tillman, M.C. / Sugiyama, A. ...Druzak, S.A. / Tardelli, M. / Mays, S.G. / El Bejjani, M. / Mo, X. / Maner-Smith, K.M. / Bowen, T. / Cato, M.L. / Tillman, M.C. / Sugiyama, A. / Xie, Y. / Fu, H. / Cohen, D.E. / Ortlund, E.A.
External linksNat Commun / PubMed:37173315
MethodsX-ray diffraction
Resolution2.18 Å
Structure data

PDB-7u9d:
Crystal Structure of Human Phosphatidylcholine Transfer Protein in Complex with PC(16:0/20:4)
Method: X-RAY DIFFRACTION / Resolution: 2.18 Å

Chemicals

ChemComp-M2R:
[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] (5~{Z},8~{Z},11~{Z},14~{Z})-icosa-5,8,11,14-tetraenoate

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / Phosphatidylcholine transfer protein / PC(16:0/20:4) / Complex / Ligand

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