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-Structure paper
Title | Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 15679-15697, Year 2022 |
Publish date | Mar 10, 2022 (structure data deposition date) |
Authors | Amrhein, J.A. / Beyett, T.S. / Feng, W.W. / Kramer, A. / Weckesser, J. / Schaeffner, I.K. / Rana, J.K. / Janne, P.A. / Eck, M.J. / Knapp, S. / Hanke, T. |
External links | J. Med. Chem. / PubMed:36384036 |
Methods | X-ray diffraction |
Resolution | 2.5 - 3.42 Å |
Structure data | PDB-7u98: PDB-7u99: PDB-7u9a: |
Chemicals | ChemComp-M1O: ChemComp-M0R: ChemComp-FLC: ChemComp-HOH: ChemComp-M19: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / EGFR / kinase / macrocycle / inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex |