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-Structure paper
Title | Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. |
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Journal, issue, pages | Cell Chem Biol, Vol. 30, Page 235-247.e12, Year 2023 |
Publish date | Mar 8, 2022 (structure data deposition date) |
![]() | Bonazzi, S. / d'Hennezel, E. / Beckwith, R.E.J. / Xu, L. / Fazal, A. / Magracheva, A. / Ramesh, R. / Cernijenko, A. / Antonakos, B. / Bhang, H.C. ...Bonazzi, S. / d'Hennezel, E. / Beckwith, R.E.J. / Xu, L. / Fazal, A. / Magracheva, A. / Ramesh, R. / Cernijenko, A. / Antonakos, B. / Bhang, H.C. / Caro, R.G. / Cobb, J.S. / Ornelas, E. / Ma, X. / Wartchow, C.A. / Clifton, M.C. / Forseth, R.R. / Fortnam, B.H. / Lu, H. / Csibi, A. / Tullai, J. / Carbonneau, S. / Thomsen, N.M. / Larrow, J. / Chie-Leon, B. / Hainzl, D. / Gu, Y. / Lu, D. / Meyer, M.J. / Alexander, D. / Kinyamu-Akunda, J. / Sabatos-Peyton, C.A. / Dales, N.A. / Zecri, F.J. / Jain, R.K. / Shulok, J. / Wang, Y.K. / Briner, K. / Porter, J.A. / Tallarico, J.A. / Engelman, J.A. / Dranoff, G. / Bradner, J.E. / Visser, M. / Solomon, J.M. |
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Methods | X-ray diffraction |
Resolution | 3.15 - 3.7 Å |
Structure data | ![]() PDB-7u8f: ![]() PDB-8dey: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-LWK: ![]() ChemComp-SO4: ![]() ChemComp-EPE: ![]() ChemComp-HOH: |
Source |
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![]() | LIGASE / molecular glue / targeted protein degradation / E3 ligase / complex |