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TitleDesign and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.
Journal, issue, pagesBioorg. Med. Chem., Vol. 66, Page 116820-116820, Year 2022
Publish dateFeb 25, 2022 (structure data deposition date)
AuthorsKawamura, S. / Palte, R.L. / Kim, H.Y. / Sauri, J. / Sondey, C. / Mansueto, M.S. / Altman, M.D. / Machacek, M.R.
External linksBioorg. Med. Chem. / PubMed:35594650
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-7u30:
PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-LB3:
(9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / PRMT5 / Inhibitor / Cyclonucleoside / Methyl Transferase

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