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-Structure paper
Title | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. |
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Journal, issue, pages | Antimicrob. Agents Chemother., Vol. 66, Page e0241421-e0241421, Year 2022 |
Publish date | Dec 21, 2021 (structure data deposition date) |
Authors | Alsenani, T.A. / Viviani, S.L. / Kumar, V. / Taracila, M.A. / Bethel, C.R. / Barnes, M.D. / Papp-Wallace, K.M. / Shields, R.K. / Nguyen, M.H. / Clancy, C.J. ...Alsenani, T.A. / Viviani, S.L. / Kumar, V. / Taracila, M.A. / Bethel, C.R. / Barnes, M.D. / Papp-Wallace, K.M. / Shields, R.K. / Nguyen, M.H. / Clancy, C.J. / Bonomo, R.A. / van den Akker, F. |
External links | Antimicrob. Agents Chemother. / PubMed:35341315 |
Methods | X-ray diffraction |
Resolution | 0.99 - 3.16 Å |
Structure data | PDB-7tb7: PDB-7tbx: PDB-7tc1: |
Chemicals | ChemComp-CIT: ChemComp-HOH: ChemComp-4D6: ChemComp-PO4: |
Source |
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Keywords | HYDROLASE / beta-lactamase / antibiotic resistance |