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TitleSARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
Journal, issue, pagesScience, Vol. 375, Issue 6582, Page 760-764, Year 2022
Publish dateFeb 18, 2022
AuthorsDhiraj Mannar / James W Saville / Xing Zhu / Shanti S Srivastava / Alison M Berezuk / Katharine S Tuttle / Ana Citlali Marquez / Inna Sekirov / Sriram Subramaniam /
PubMed AbstractThe newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex ...The newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hydrogen bonds formed by mutated residues R493, S496 and R498 in the RBD with ACE2. These interactions appear to compensate for other Omicron mutations such as K417N known to reduce ACE2 binding affinity, resulting in similar biochemical ACE2 binding affinities for Delta and Omicron variants. Neutralization assays show that pseudoviruses displaying the Omicron spike protein exhibit increased antibody evasion. The increase in antibody evasion, together with retention of strong interactions at the ACE2 interface, thus represent important molecular features that likely contribute to the rapid spread of the Omicron variant.
External linksScience / PubMed:35050643 / PubMed Central
MethodsEM (single particle)
Resolution2.45 - 2.79 Å
Structure data

25759

7t9j

EMDB-25759, PDB-7t9j:
Cryo-EM structure of the SARS-CoV-2 Omicron spike protein
Method: EM (single particle) / Resolution: 2.79 Å

25760

7t9k

EMDB-25760, PDB-7t9k:
Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2
Method: EM (single particle) / Resolution: 2.45 Å

25761

7t9l

EMDB-25761, PDB-7t9l:
Cryo-EM structure of SARS-CoV-2 Omicron spike protein in complex with human ACE2 (focused refinement of RBD and ACE2)
Method: EM (single particle) / Resolution: 2.66 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / SARS-CoV-2 / glycoprotein / fusion protein / ACE2

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