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TitleEvasion of cGAS and TRIM5 defines pandemic HIV.
Journal, issue, pagesNat Microbiol, Vol. 7, Page 1762-1776, Year 2022
Publish dateNov 26, 2021 (structure data deposition date)
AuthorsZuliani-Alvarez, L. / Govasli, M.L. / Rasaiyaah, J. / Monit, C. / Perry, S.O. / Sumner, R.P. / McAlpine-Scott, S. / Dickson, C. / Rifat Faysal, K.M. / Hilditch, L. ...Zuliani-Alvarez, L. / Govasli, M.L. / Rasaiyaah, J. / Monit, C. / Perry, S.O. / Sumner, R.P. / McAlpine-Scott, S. / Dickson, C. / Rifat Faysal, K.M. / Hilditch, L. / Miles, R.J. / Bibollet-Ruche, F. / Hahn, B.H. / Boecking, T. / Pinotsis, N. / James, L.C. / Jacques, D.A. / Towers, G.J.
External linksNat Microbiol / PubMed:36289397
MethodsX-ray diffraction
Resolution2.05 - 3.3 Å
Structure data

PDB-7qdf:
Hexameric HIV-1 (M-group) CA R120 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.304 Å

PDB-7t12:
Hexameric HIV-1 (O-group) CA
Method: X-RAY DIFFRACTION / Resolution: 3.0 Å

PDB-7t13:
Hexameric HIV-1 (M-group) CA Q50Y mutant
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-7t14:
Hexameric SIVmac CA
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-7t15:
Hexameric SIVcpz CA
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-8d3b:
Hexameric HIV-1 (M-group) Q50Y/R120 mutant
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-IOD:
IODIDE ION / Iodide

ChemComp-CL:
Unknown entry / Chloride

ChemComp-BME:
BETA-MERCAPTOETHANOL / 2-Mercaptoethanol

ChemComp-HOH:
WATER / Water

Source
  • human immunodeficiency virus type 1 group m subtype b (isolate ny5)
  • hiv-1 o_mvp5180 (virus)
  • hiv-1 group m (virus)
  • simian immunodeficiency virus (mm251 isolate)
  • simian immunodeficiency virus - cpz
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN / HIV-1 CAPSID PROTEIN / HEXAMER / R120 MUTANT / Capsid

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