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TitleStaphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Journal, issue, pagesNat. Immunol., Vol. 24, Page 110-122, Year 2023
Publish dateOct 7, 2021 (structure data deposition date)
AuthorsMonnot, G.C. / Wegrecki, M. / Cheng, T.Y. / Chen, Y.L. / Sallee, B.N. / Chakravarthy, R. / Karantza, I.M. / Tin, S.Y. / Khaleel, A.E. / Monga, I. ...Monnot, G.C. / Wegrecki, M. / Cheng, T.Y. / Chen, Y.L. / Sallee, B.N. / Chakravarthy, R. / Karantza, I.M. / Tin, S.Y. / Khaleel, A.E. / Monga, I. / Uwakwe, L.N. / Tillman, A. / Cheng, B. / Youssef, S. / Ng, S.W. / Shahine, A. / Garcia-Vilas, J.A. / Uhlemann, A.C. / Bordone, L.A. / Han, A. / Rohde, C.H. / Ogg, G. / Moody, D.B. / Rossjohn, J. / de Jong, A.
External linksNat. Immunol. / PubMed:36550321
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-7sh4:
CD1a-phosphatidylglycerol binary structure
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MW9:
(21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD1 / antigen presentation / lipid / phospholipid

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