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-Structure paper
Title | Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 144, Page 18861-18875, Year 2022 |
Publish date | Oct 5, 2021 (structure data deposition date) |
![]() | Steimbach, R.R. / Herbst-Gervasoni, C.J. / Lechner, S. / Stewart, T.M. / Klinke, G. / Ridinger, J. / Geraldy, M.N.E. / Tihanyi, G. / Foley, J.R. / Uhrig, U. ...Steimbach, R.R. / Herbst-Gervasoni, C.J. / Lechner, S. / Stewart, T.M. / Klinke, G. / Ridinger, J. / Geraldy, M.N.E. / Tihanyi, G. / Foley, J.R. / Uhrig, U. / Kuster, B. / Poschet, G. / Casero Jr., R.A. / Medard, G. / Oehme, I. / Christianson, D.W. / Gunkel, N. / Miller, A.K. |
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Methods | X-ray diffraction |
Resolution | 2.1 - 2.2 Å |
Structure data | ![]() PDB-7sgg: ![]() PDB-7sgi: ![]() PDB-7sgj: ![]() PDB-7sgk: |
Chemicals | ![]() ChemComp-SHH: ![]() ChemComp-PEG: ![]() ChemComp-ZN: ![]() ChemComp-K: ![]() ChemComp-PO4: ![]() ChemComp-NA: ![]() ChemComp-HOH: ![]() ChemComp-9DL: ![]() ChemComp-9BI: ![]() ChemComp-EDO: ![]() ChemComp-9A9: |
Source |
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![]() | HYDROLASE / Histone Deacetylase |