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-Structure paper
Title | Inhibitors of Mycobacterium tuberculosis EgtD target both substrate binding sites to limit hercynine production. |
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Journal, issue, pages | Sci Rep, Vol. 11, Page 22240-22240, Year 2021 |
Publish date | Sep 28, 2021 (structure data deposition date) |
Authors | Sudasinghe, T.D. / Banco, M.T. / Ronning, D.R. |
External links | Sci Rep / PubMed:34782676 |
Methods | X-ray diffraction |
Resolution | 1.72 - 2.67 Å |
Structure data | PDB-7scf: PDB-7sew: PDB-7sex: PDB-7sey: PDB-7sf4: PDB-7sf5: |
Chemicals | ChemComp-8YI: ChemComp-PEG: ChemComp-GOL: ChemComp-PO4: ChemComp-HOH: ChemComp-PDO: ChemComp-A1I: ChemComp-93I: ChemComp-92W: ChemComp-XDK: ChemComp-EDO: ChemComp-95I: |
Source |
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Keywords | TRANSFERASE / Ergothioneine biosynthesis pathway / Rossmann fold domain / histidine/histamine derivatives / SAM dependent methyltransferase / bi-substrate analogs / histidine binding site / SAM dependent methyl transferase / peptide like inhibitor / SAM binding domain / Histidine binding domain |