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-Structure paper
Title | Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. |
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Journal, issue, pages | Science, Vol. 376, Page 1074-1079, Year 2022 |
Publish date | Aug 2, 2021 (structure data deposition date) |
![]() | Xie, S.C. / Metcalfe, R.D. / Dunn, E. / Morton, C.J. / Huang, S.C. / Puhalovich, T. / Du, Y. / Wittlin, S. / Nie, S. / Luth, M.R. ...Xie, S.C. / Metcalfe, R.D. / Dunn, E. / Morton, C.J. / Huang, S.C. / Puhalovich, T. / Du, Y. / Wittlin, S. / Nie, S. / Luth, M.R. / Ma, L. / Kim, M.S. / Pasaje, C.F.A. / Kumpornsin, K. / Giannangelo, C. / Houghton, F.J. / Churchyard, A. / Famodimu, M.T. / Barry, D.C. / Gillett, D.L. / Dey, S. / Kosasih, C.C. / Newman, W. / Niles, J.C. / Lee, M.C.S. / Baum, J. / Ottilie, S. / Winzeler, E.A. / Creek, D.J. / Williamson, N. / Parker, M.W. / Brand, S. / Langston, S.P. / Dick, L.R. / Griffin, M.D.W. / Gould, A.E. / Tilley, L. |
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Methods | X-ray diffraction |
Resolution | 1.7 - 2.2 Å |
Structure data | ![]() PDB-7ror: ![]() PDB-7ros: ![]() PDB-7rot: ![]() PDB-7rou: |
Chemicals | ![]() ChemComp-69X: ![]() ChemComp-MLI: ![]() ChemComp-CL: ![]() ChemComp-MG: ![]() ChemComp-HOH: ![]() ChemComp-66I: ![]() ChemComp-SO4: |
Source |
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![]() | LIGASE / enzyme / tyrosyl-tRNA synthetase / malaria / inhibitor / tyrosine-AMP |