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Title | An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19. |
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Journal, issue, pages | Science, Vol. 374, Page 1586-1593, Year 2021 |
Publish date | Jul 14, 2021 (structure data deposition date) |
![]() | Owen, D.R. / Allerton, C.M.N. / Anderson, A.S. / Aschenbrenner, L. / Avery, M. / Berritt, S. / Boras, B. / Cardin, R.D. / Carlo, A. / Coffman, K.J. ...Owen, D.R. / Allerton, C.M.N. / Anderson, A.S. / Aschenbrenner, L. / Avery, M. / Berritt, S. / Boras, B. / Cardin, R.D. / Carlo, A. / Coffman, K.J. / Dantonio, A. / Di, L. / Eng, H. / Ferre, R. / Gajiwala, K.S. / Gibson, S.A. / Greasley, S.E. / Hurst, B.L. / Kadar, E.P. / Kalgutkar, A.S. / Lee, J.C. / Lee, J. / Liu, W. / Mason, S.W. / Noell, S. / Novak, J.J. / Obach, R.S. / Ogilvie, K. / Patel, N.C. / Pettersson, M. / Rai, D.K. / Reese, M.R. / Sammons, M.F. / Sathish, J.G. / Singh, R.S.P. / Steppan, C.M. / Stewart, A.E. / Tuttle, J.B. / Updyke, L. / Verhoest, P.R. / Wei, L. / Yang, Q. / Zhu, Y. |
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Methods | X-ray diffraction |
Resolution | 1.626 - 2.498 Å |
Structure data | ![]() PDB-7rfr: ![]() PDB-7rfs: ![]() PDB-7rfu: ![]() PDB-7rfw: |
Chemicals | ![]() ChemComp-4W8: ![]() ChemComp-HOH: ![]() ChemComp-4WI: ![]() ChemComp-4YG: |
Source |
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![]() | HYDROLASE/INHIBITOR / Protease SARS-CoV-2 Covalent complex inhibitor / HYDROLASE-INHIBITOR complex |