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TitlePhysachenolide C is a Potent, Selective BET Inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 913-933, Year 2023
Publish dateJun 27, 2021 (structure data deposition date)
AuthorsZerio, C.J. / Sivinski, J. / Wijeratne, E.M.K. / Xu, Y.M. / Ngo, D.T. / Ambrose, A.J. / Villa-Celis, L. / Ghadirian, N. / Clarkson, M.W. / Zhang, D.D. ...Zerio, C.J. / Sivinski, J. / Wijeratne, E.M.K. / Xu, Y.M. / Ngo, D.T. / Ambrose, A.J. / Villa-Celis, L. / Ghadirian, N. / Clarkson, M.W. / Zhang, D.D. / Horton, N.C. / Gunatilaka, A.A.L. / Fromme, R. / Chapman, E.
External linksJ. Med. Chem. / PubMed:36577036
MethodsX-ray diffraction
Resolution1.8 - 2.89 Å
Structure data

PDB-7r8r:
Physachenolide C with Bromodomain (BRD3-BD1)
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7s3p:
BD2 domain of human BRD3 bound to Physachenolide C
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

Chemicals

ChemComp-8L6:
Physachenolide C

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / bromodomain 3 / physachenolide C / prostate cancer / TRANSCRIPTION / inhibitor / bromodomain / epigenetics

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